Autoimmunity and Graves’ Disease

Anticardiolipin Antibodies and Immunoglobulin M and A in Graves’ Disease

Background: Graves’ disease is an autoimmune disease, characterized by the presence of antibodies directed to TSH receptor or nearby regions as well as antibodies to double strands DNA (dsDNA) anticardiolipin and nuclear antibodies. This study evaluated anticardiolipin and rheumatoid factor, such as IgA and IgM antibodies in patients with Graves’ disease. Patients and methods: Anticardiolipin a...

Correlation between thyroid volume and humoral thyroid autoimmunity after radioiodine therapy in Graves' disease.

BACKGROUND Graves' disease is an autoimmune disorder with the presence of TSH receptor autoantibodies (TRAb). TRAb are produced mainly by lymphocytes infiltrating the thyroid gland. The aim of this study was to investigate the influence of the reduction of thyroid volume (TV) on TRAb level after radioiodine (RAI) administration in a group of patients with Graves' disease. MATERIAL AND METHODS...

Anti-pancreatic autoimmunity and Graves' disease: study of a cohort of 600 Caucasian patients.

The aim of this study was to investigate the frequencies of clinical diabetes and humoral markers of anti-pancreatic autoimmunity in a homogeneous population of 600 Caucasian patients with recently diagnosed Graves' disease (GD), in order to characterize the specific features of this group of endocrine patients among subjects at risk of diabetes. Ten were already diabetic at GD diagnosis. Among...

Metamorphic thyroid autoimmunity in Down Syndrome: from Hashimoto’s thyroiditis to Graves’ disease and beyond

BACKGROUND It is known that Hashimoto's thyroiditis (HT) may progress to Graves' disease (GD) and that this phenomenon may be more frequent in the patients with Down syndrome (DS). AIMS To shed light on the relationships between Down syndrome (DS) and metamorphic thyroid autoimmunity. PATIENTS AND METHODS We reconstructed the conversion process from HT to GD in 12 DS children. All the data ...

[Graves' disease].